Not really, if you did all the creating mods and the ECU did nothing, it would run very lean and could cause damage to the engine.
wouldn't it do the opposite and run rich in order to protect the engine? surely if you had more air going in it would compensate with more fuel? but then again if the ECU did nothing then why would it run lean or rich?
That was supposed to read breathing mods, oops
Anyway, the ECU can only correct so much, so ultimately after you fit a FULL exhaust with decats etc, new plenum/spacer, high flow filter etc, there will be more air than the ECU can tune out.