Hi, i sold my S2000 for a 350 and very happy with my decision so far, even tho i loved the s2000, it was better handling because its much lighter but you have to be constantly up and down through the gearbox and screaming the titties off it to go anywhere and sitting at 4k through town is not a good look, theyre an ass to drive smooth slowly or in traffic and unless its a hardtop youll be deaf when you get there. But through some twisties with some decent tires will destory almost anything beware they are very snatchy when it does let go and you're usually going fairly quick when it does. 350 is easier to drive, easier to slide, much much more powerful, more comfortable and still bags of fun also your not crippled/deaf when you arrive. Plus looks more expensive in the car park and you dont get dickheads calling you a hairdresser/ confusing it with an MX5.
Sorry for the essay but hope this helps.